The Ludwig Boltzmann Gesellschaft is a research institution with a thematic focus on medicine, life sciences and the humanities, social sciences and cultural sciences, and is specifically targeting new research topics in Austria. Together with academic and implementing partners, the LBG is currently running 18 institutes and develops and tests new forms of collaboration between science and non-scientific actors such as companies, the public sector and civil society. Socially relevant challenges, to which research can contribute, are to be recognized at an early stage and taken up. In 2016, the LBG Career Center, which is supporting 200 pre and postdocs, has been set up. In addition, the LBG Open Innovation in Science Center (LBG OIS Center), which is revealing the potential of open innovation to science, was launched. The Ludwig Boltzmann Gesellschaft employs 550 people. The total budget for the year 2016 amounted to 28.4 million euros, about 30 percent of the funds come from the budget of the Federal Ministry of Science, Research and Economy.Open Innovation in Science can unfold its potential for scientific research activities such as generating novel research questions, designing and conducting research studies, disseminating research results and eventually translating new scientific knowledge into innovation.